The CTDSP2 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated from Bioss Inc. is a Rabbit Polyclonal antibody to CTDSP2. This antibody recognizes Human, and Rat antigen. The CTDSP2 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated has been validated for the following applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, and Immunohistochemistry - frozen.
Description
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas